Dr. Hsiu-Ming Shih

Hsiu-Ming Shih, Ph.D.

Distinguished Investigator & Director
Institute of Molecular and Genomic Medicine
hmshih@nhri.edu.tw

EDUCATION

1989-1993    Ph. D., Dept. of Biochemistry, University of Minnesoda, Minneapolis, USA
1982-1986    B.S., Dept. of Medical Technology, National Taiwan University, Taipei, Taiwan

PROFESSIONAL EXPERIENCES

2017 – present    Distinguished Investigator and Director, Institute of Molecular and Genomic Medicine, National Health Research Institute

2015 – present    Research Fellow, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2012 – 2014    Research Fellow and Deputy Director, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2007 – 2011    Research Fellow and Division Coordinator, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2005 – 2007    Associate Research Fellow, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2004 – 2004    Associate Investigator, Division of Molecular and Genomic Medicine, National Health Research Institute, Taipei, Taiwan
1997 – 2002    Assistant Investigator, Division of Molecular and Genomic Medicine, National Health Research Institute, Taipei, Taiwan
1996 – 1997    Instructor, School and Graduate Institute of Medical Technology, National Taiwan University, Taipei, Taiwan

HONORS & AWARDS

2013    The 23rd Wang Min-Ning Memorial Award for Outstanding Contribution to the Medical Science and Technology Development, Health and Society
2012    Frontier Science Award, National Science Council
2010    Distinguished Research Award, National Science Council
2007    Frontier Science Award, National Science Council
2007    The 3rd Yung Shih Lee Tian-De Medical and Pharmaceutical Science and Technology Award-Young Scientist Research Scholarship
2007    Academia Sinica Investigator Award
2006    Distinguished Research Award, National Science Council
2005    Academia Sinica Young Investigator Award
1997    FASEB Young Investigator Award

SELECTED PUBLICATIONS

1. Naik MT, Kang M, Ho CC, Hsieh YL, Nail NM, Wang SH, Chang I*, Shih HM*, and Huang TH*.  Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction.  Scientific Reports 7(1), 17391 (2017-12)

2. Lin YM, Wang CM, Jeng JC, Leprince D, and Shih HM*.  HIC1 interacts with and modulates the activity of STAT3.  CELL CYCLE 12(14), 2266-2276 (2013-07)

3. Hsieh YL, Kuo HY, Chang CC, Naik MT, Liao PH, Ho CC, Huang TC, Jeng JC, Hsu PH, Tsai MD, Huang TH and Shih, HM*.  Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.  EMBO JOURNAL 32(6), 791-804 (2013-03)

4. Yang WC and Shih HM*.  Deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability ONCOGENE 32(43), 5167-5175 (2012-12)

5. Huang, YS, Chang, CC, Hsieh, YL, Huang, TC, and Shih, HM*.  Daxx interacts with and modulates the activity of CREB.  CELL CYCLE 11, 99-108 (2012-01)

6. Chen, SC, Chang LY, Wang, YW, Chen, YC, Weng, KF, Shih, SR and Shih, HM*. Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis.  JOURNAL OF BIOLOGICAL CHEMISTRY 286, 31373-31384 (2011-09)

7. Chang, CC, Naik, MT, Huang, YS, Jeng, JC, Liao, PH, Kuo, HY, Ho, CC, Hsieh, YL, Lin, CH, Huang, NJ, Naik, NM, Kung, CC-H, Lin, SY, Chen, RH, Chang, KS, Huang, TH *, and Shih, HM*.  Structural and functional roles of Daxx SIM phosphorylation in SUMO paralogue-selective binding and apoptosis modulation.  MOLECULAR CELL 42(1), 62-74 (2011-04)

8. Jeng, JC, Lin, YM, Lin, CH, and Shih, HM*.  Cdh1 controls the stability of TACC3.  Cell Cycle 8(21), 3529-36 (2009-11)

9. D. Y. Lin, Y. S. Huang, J. C. Jeng, H. Y. Kuo, C. C. Chang, T. T. Chao, C. C. Ho, Y. C. Chen, T. P. Lin, H. I. Fang, C. C. Hung, C. S. Suen, M. J. Hwang, K. S. Chang, G. G. Maul and H. M. Shih Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and respression of sumoylated transcription factors.  Mol Cell 24(3), 341-354 (2006)

10. C. C. Chang, D. Y. Lin, H. I. Fang, R. H. Chen and H. M. Shih Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.  J Biol Chem 280, 10164-10173 (2005)

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