Yun-Jin Jiang, Ph.D.
Institute of Molecular and Genomic Medicine
|1992/10 – 1997/01||Ph.D., Genetics/Developmental Biology, Eberhard-Karls Universitaet (Tuebingen University), Germany|
|1986/09 – 1998/06||M.Sc., Biochemistry, National Taiwan University, Taiwan|
|1982/09 – 1986/06||B.Sc., Agricultural Chemistry, National Taiwan University, Taiwan|
|2009/09 – present||Assiciate Investigator, Division of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan|
|2008/01 – 2009/09||Adjunct Associate Professor, Department of Biochemistry, National University of Singapore, Singapore|
|2006/10 – 2009/06||Adjunct Associate Professor, School of Biological Sciences, Nanyang Technological University, Singapore|
|2003/04 – 2009/09||Faculty, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore|
|2003/03 – 2007/12||Adjunct Assistant Professor, Department of Biochemistry, National University of Singapore, Singapore|
|2002/08 – 2009/09||Principal Investigator, Laboratory of Developmental Signalling and Patterning, Institute of Molecular and Cell Biology, Singapore|
|2001/09 – 2002/07||Principal Investigator, Laboratory of Developmental Signalling and Patterning, Institute of Molecular Agrobiology, Singapore|
|1997/01 – 2001/08||Postdoc, Vertebrate Development Laboratory,Imperial Cancer Research Fund, UK|
We are interested in understanding the functions of Notch signaling pathway: how it controls pattern formation, cell fate determination and cell differentiation in many different tissues, at many different times; and, furthermore, to dissect the mechanism of Notch activation. As a developmental biology-oriented laboratory, we mainly use zebrafish as a model system to explore the developmental mechanisms and, hopefully, pathology related to Notch signaling. We also extend our interest to other signaling pathways, largely, the Wnt signaling pathway, since it interacts, in several contexts, with Notch signaling. In addition, we examine the phenotypes of udu mutants and function of Udu, which genetically interacts with Mib.
Presently, the lab is focusing on Mindbomb (Mib), a novel component of Notch signaling, and Ugly duckling (Udu), a novel protein that is likely be required for DNA replication. The ongoing projects are
- to analyze the role of Udu in DNA replication; and
- to dissect the function of Notch signaling in pronephric tubule.
In the future, we would like
- to discover the roles of deubiquitylating enzymes (DUBs) in Notch signaling and their interactions with Mib E3 ligase and its homolog, Mib2;
- to examine the phenotypes and analyze the transcriptome of zebrafish nicastrin (in association with other proteins, including Presenilin, to behave as g-secretase) mutants and its potential link to Alzheime’s disease;
- to find out the relationship between Notch signaling and Udu protein;
- to explore the functions of Mib/Mib2 and Mib/Mib2-interacting proteins in relation to Notch signaling and probably other pathways;
- to understand the role of Wnt signaling in muscle attachment and
- to study the function of Notch signaling and other related genes in hindbrain boundary formation.
HONORS & AWARDS
|2007||(2007) UK-Singapore Partners in Science Collaboration Development Awards|
|1999 – 2001||(1999/1-2001/8) Imperial Cancer Research Fund (ICRF) Research Fellowship (UK)|
|1997 – 1999||(1997/1-1998/12) European Molecular Biology Organization (EMBO) Fellowship (EU)|
|1992 – 1997||(1992/8-1996/12) Deutscher Akademischer Austauschdienst (DAAD) Stipendium (FRG)|
|1986 – 1988||(1986/9-1988/6) Graduate Studentship from the Ministry of Education (Taiwan/ROC)|
SELECTED PUBLICATIONS (Since 2009)
- Jiang, Y.-J.*, Brand, M., Heisenberg, C.-P., Beuchle, D., Furutani-Seiki, M., Kelsh, R. N., Warga, R. M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D. A., Mullins, M. C., Odenthal, J., van Eeden, F. J. M. and Nüsslein-Volhard, C. (1996). Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development 123, 205-216. (IF=9.182; cited=250)
- Jiang, Y.-J., Aerne, B. L., Smithers, L., Haddon, C., Ish-Horowicz, D. and Lewis, J. (2000). Notch signalling and the synchronization of the somite segmentation clock. Nature, 408, 475-479; doi :10.1038/35044091. (recommended in Faculty of 1000, 12/2001) (IF=29.491; cited=363)
- Ma, M. and Jiang, Y.-J.* (2007). Jagged2a-Notch signaling mediates cell fate choice in zebrafish pronephric duct. PLoS Genet., 3, e18; doi: 10.1371/journal.pgen.0030018. (IF=7.671; cited=80)
- Hegde, A., Qiu, N. C., Qiu, X., Ho, S. H.-K., Tay, K. Q.-Y., George, J., Ng, F. S. L., Govindarajan, K. R., Gong, Z., Mathavan, S. and Jiang, Y.-J.* (2008). Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genes. PLoS ONE, 3, e1479; doi: 10.1371/journal.pone.0001479. (IF=4.351; cited=12)
- Lim, C.-H., Chong, S.-W. and Jiang, Y.-J.* (2009). Udu deficiency activates DNA damage checkpoint. Mol. Biol. Cell, 20, 4183-4193; doi: 10.1091/mbc.E09-02-0109. (IF=5.558; cited=9)
- Tse, W. K. F., Eisenhaber, B., Ho, S. H.-K., Ng, Q., Eisenhaber, F. and Jiang, Y.-J.* (2009). Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics, 10, 637; doi: 10.1186/1471-2164-10-637. (IF=3.926; cited=40)
- Tseng, L.-C., Zhang, C., Cheng, C.-M., Xu, H., Hsu, C.-H. and Jiang, Y.-J.* (2014). New classes of Mind bomb-interacting proteins identified from yeast two-hybrid screens. PLoS ONE, 9, e93394; doi: 10.1371/journal.pone.0093394. (IF=3.534; cited=17)
- Hsu, C.-H., Lin, J.-S., Lai, K. P., Li, J.-W., Chan, T.-F., You, M.-S., Tse, W. K. F. and Jiang, Y.-J.* (2015). A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect. Sci. Rep., 5, 10673; doi: 10.1038/srep10673. (IF=5.578; cited=3)
- Wu, J.-H., Liu, J.-H., Ko, Y.-C., Wang, C.-T., Chung, Y.-C., Chu, K.-C., Liu, T.-T., Chao, H.-M., Jiang, Y.-J.* Chen, S.-J. and Chung, M.-Y. (2016). Haploinsufficiency of RCBTB1 is associated with Coats Disease and Familial Exudative Vitreoretinopathy. Hum. Mol. Genet., 25, 1637-1647; doi: 10.1093/hmg/ddw041. (*co-corresponding author). (IF=5.985; cited=10)
- Hsu, C.-H., Liou, G.-G. and Jiang, Y.-J.* (2019). Nicastrin deficiency induces Tyrosinase-dependent depigmentation and skin inflammation. J. Invest. Derma., in press; doi: 10.1016/j.jid.2019.07.702.