Hsiu-Ming Shih, Ph.D.
Distinguished Investigator & Director
Institute of Molecular and Genomic Medicine
hmshih@nhri.edu.tw
EDUCATION
1989-1993 Ph. D., Dept. of Biochemistry, University of Minnesoda, Minneapolis, USA
1982-1986 B.S., Dept. of Medical Technology, National Taiwan University, Taipei, Taiwan
PROFESSIONAL EXPERIENCES
2017 – present Distinguished Investigator and Director, Institute of Molecular and Genomic Medicine, National Health Research Institute
2015 – present Research Fellow, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2012 – 2014 Research Fellow and Deputy Director, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2007 – 2011 Research Fellow and Division Coordinator, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2005 – 2007 Associate Research Fellow, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
2004 – 2004 Associate Investigator, Division of Molecular and Genomic Medicine, National Health Research Institute, Taipei, Taiwan
1997 – 2002 Assistant Investigator, Division of Molecular and Genomic Medicine, National Health Research Institute, Taipei, Taiwan
1996 – 1997 Instructor, School and Graduate Institute of Medical Technology, National Taiwan University, Taipei, Taiwan
HONORS & AWARDS
2013 The 23rd Wang Min-Ning Memorial Award for Outstanding Contribution to the Medical Science and Technology Development, Health and Society
2012 Frontier Science Award, National Science Council
2010 Distinguished Research Award, National Science Council
2007 Frontier Science Award, National Science Council
2007 The 3rd Yung Shih Lee Tian-De Medical and Pharmaceutical Science and Technology Award-Young Scientist Research Scholarship
2007 Academia Sinica Investigator Award
2006 Distinguished Research Award, National Science Council
2005 Academia Sinica Young Investigator Award
1997 FASEB Young Investigator Award
SELECTED PUBLICATIONS
1. Naik MT, Kang M, Ho CC, Hsieh YL, Nail NM, Wang SH, Chang I*, Shih HM*, and Huang TH*. Molecular mechanism of K65 acetylation-induced attenuation of Ubc9 and the NDSM interaction. Scientific Reports 7(1), 17391 (2017-12)
2. Lin YM, Wang CM, Jeng JC, Leprince D, and Shih HM*. HIC1 interacts with and modulates the activity of STAT3. CELL CYCLE 12(14), 2266-2276 (2013-07)
3. Hsieh YL, Kuo HY, Chang CC, Naik MT, Liao PH, Ho CC, Huang TC, Jeng JC, Hsu PH, Tsai MD, Huang TH and Shih, HM*. Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response. EMBO JOURNAL 32(6), 791-804 (2013-03)
4. Yang WC and Shih HM*. Deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability ONCOGENE 32(43), 5167-5175 (2012-12)
5. Huang, YS, Chang, CC, Hsieh, YL, Huang, TC, and Shih, HM*. Daxx interacts with and modulates the activity of CREB. CELL CYCLE 11, 99-108 (2012-01)
6. Chen, SC, Chang LY, Wang, YW, Chen, YC, Weng, KF, Shih, SR and Shih, HM*. Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY 286, 31373-31384 (2011-09)
7. Chang, CC, Naik, MT, Huang, YS, Jeng, JC, Liao, PH, Kuo, HY, Ho, CC, Hsieh, YL, Lin, CH, Huang, NJ, Naik, NM, Kung, CC-H, Lin, SY, Chen, RH, Chang, KS, Huang, TH *, and Shih, HM*. Structural and functional roles of Daxx SIM phosphorylation in SUMO paralogue-selective binding and apoptosis modulation. MOLECULAR CELL 42(1), 62-74 (2011-04)
8. Jeng, JC, Lin, YM, Lin, CH, and Shih, HM*. Cdh1 controls the stability of TACC3. Cell Cycle 8(21), 3529-36 (2009-11)
9. D. Y. Lin, Y. S. Huang, J. C. Jeng, H. Y. Kuo, C. C. Chang, T. T. Chao, C. C. Ho, Y. C. Chen, T. P. Lin, H. I. Fang, C. C. Hung, C. S. Suen, M. J. Hwang, K. S. Chang, G. G. Maul and H. M. Shih Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and respression of sumoylated transcription factors. Mol Cell 24(3), 341-354 (2006)
10. C. C. Chang, D. Y. Lin, H. I. Fang, R. H. Chen and H. M. Shih Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4. J Biol Chem 280, 10164-10173 (2005)