Shao-Win Wang, Ph.D.
Institute of Molecular and Genomic Medicine
Ph.D., Department of Biological and Chemical Science, University of Essex, UK, 1997
M.Sc., Institute of Medicine, Chung-Shan Medical and Dental College, Taiwan, 1992
B.Sc., School of Nutrition, Chung-Shan Medical and Dental College, Taiwan, 1988
Assistant Investigator, Division of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan (2007-present)
Wellcome Trust RCDF Fellow, Department of Zoology, University of Oxford, UK (2002-2007)
Postdoctoral Fellow, Cancer Research UK Laboratories, University of Oxford, Weatherall Institute of Molecular Medicine, UK (1997-2002)
Dr. Wang has made use of post-genomic studies of the fission yeast Schizosaccharomyces pombe, which is well established as a useful model for a number aspect of cancer cell biology. His main research interest is to understand how cells maintain their genome integrity. Genome instability has been linked to diseases such as neuron degeneration, aging and development of cancer. Understand how cells maintain their genome integrity will help to improve human health. His research involves the studies of two gene families: the Cid1 family of polyA/U polymerases and the RecQ helicases in S. pombe that involve in several different aspects of chromosome function and are fundamentally important for maintenance of genome integrity
RESEARCH ACTIVITIES & ACCOMPLISHMENTS
Dr. Wang was responsible for the establishment of the research area on the Cid1 family of proteins that has proven so successful for his laboratory. This research has open up a whole new avenue of research on the role of poly(A) polymerase in DNA damage checkpoint control and chromosome dynamics. His laboratory has also provided new insight into the role of RecQ family helicases and topoisomerases III in DNA replication fork repair processes and chromosome segregation. Finally, his recent work on the Cut8 protein has generating exciting data on the connections between proteasome and DNA repair. Dr. Wang has shown the immense value of using a genetically amenable model organism to further our understanding of fundamental processes in chromosome biology.
HONORS & AWARDS
The Wellcome Trust Research Career Development Fellowship, Department of Zoology, University of Oxford, UK (2002-2006)
1. Wang SW*, Stevenson AL, Kearsey SE, Watt S, and Bähler J. Global role for polyadenylation-assisted nuclear RNA degradation in post-transcriptional gene silencing. Mol. Cell. Biol. 28: 656-665, 2008.
2. Kearsey SE, Stevenson AL, Toda T, and Wang SW*. Fission yeast Cut8 is required for the repair of DNA double-strand breaks, rDNA maintenance and cell survival in the absence of Rqh1 helicase. Mol. Cell. Biol. 27: 1558-1567, 2007.
3. Win TZ, Stevenson AL, and Wang SW*. Fission yeast Cid12 has dual functions in chromosome segregation and checkpoint control. Mol. Cell. Biol. 26: 4435-4447, 2006.
4. Win TZ, Draper S, Read RL, Pearce J, Norbury CJ, and Wang SW*. Requirement of fission yeast Cid14 in polyadenylation of ribosomal RNAs. Mol. Cell. Biol. 26: 1710-1721, 2006.
5. Win TZ, Mankouri HW, Hickson ID, and Wang SW*. A role for the fission yeast Rqh1 helicase in chromosome segregation. J. Cell Sci. 118: 5777-5784, 2005.
6. Wang SW, Asakawa K, Win TZ, Toda T, and Norbury CJ. Inactivation of the pre-mRNA cleavage and polyadenylation factor Pfs2 in fission yeast causes lethal cell cycle defects. Mol. Cell. Biol. 25: 2288-2296, 2005.
7. Win TZ, Goodwin A, Hickson ID, Norbury CJ, and Wang SW*. Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity. J. Cell Sci. 117: 4768-4778, 2004.
8. Read RL, Martinho RG, Wang SW, Carr AM, and Norbury CJ. Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest. Proc. Natl. Acad. Sci. USA 99: 12079-12084, 2002.
9. Wang SW, Goodwin A, Hickson ID, and Norbury C. Involvement of Schizosaccharomyces pombe Srs2 in cellular response to DNA damage. Nucleic Acids Res. 29: 2963-2972, 2001.
10. Wang SW, Toda T, MacCallum R, Harris AL, and Norbury C. Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase δ or ε is inactivated. Mol. Cell. Biol. 20: 3234-3244, 2000.