Yun-Jin Jiang, Ph.D.
Associate Investigator
Institute of Molecular and Genomic Medicine
EDUCATION
| 1992/10 – 1997/01 | Ph.D., Genetics/Developmental Biology, Eberhard-Karls Universitaet (Tuebingen University), Germany |
| 1986/09 – 1998/06 | M.Sc., Biochemistry, National Taiwan University, Taiwan |
| 1982/09 – 1986/06 | B.Sc., Agricultural Chemistry, National Taiwan University, Taiwan |
PROFESSIONAL EXPERIENCES
| 2009/09 – present | Assiciate Investigator, Division of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan |
| 2008/01 – 2009/09 | Adjunct Associate Professor, Department of Biochemistry, National University of Singapore, Singapore |
| 2006/10 – 2009/06 | Adjunct Associate Professor, School of Biological Sciences, Nanyang Technological University, Singapore |
| 2003/04 – 2009/09 | Faculty, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore |
| 2003/03 – 2007/12 | Adjunct Assistant Professor, Department of Biochemistry, National University of Singapore, Singapore |
| 2002/08 – 2009/09 | Principal Investigator, Laboratory of Developmental Signalling and Patterning, Institute of Molecular and Cell Biology, Singapore |
| 2001/09 – 2002/07 | Principal Investigator, Laboratory of Developmental Signalling and Patterning, Institute of Molecular Agrobiology, Singapore |
| 1997/01 – 2001/08 | Postdoc, Vertebrate Development Laboratory,Imperial Cancer Research Fund, UK |
RESEARCH INTERESTS
The research interest of our lab is focusing on animal development and human diseases by using zebrafish as a model organism. We have studied the functions of Notch and Wnt signaling in different developmental processes and disease context. Recently, the focus has gradually shifted to the IMGM thematic project: lipid metabolism and human diseases.
Ubiquitylation and deubiquitylation are important protein posttranslational modification. We have investigated this issue both in basic developmental processes and human diseases. In the future, we would like to examine the interactions and/or crosstalks between ubiquitylation/deubiquitylation and lipid metabolism-related human diseases.
Presently, the lab is focusing on Mindbomb (Mib), a novel component of Notch signaling, and Ugly duckling (Udu), a novel protein that is likely be required for DNA replication and other processes. The ongoing projects are
- to study how Zranb1 and Mib1 modulate zebrafish convergent extension through regulating Ryk trafficking;
- to study the mechanisms of Udu/GON4L on lipid metabolism and hepatocarcinogenesis;
- to study the functions of zebrafish Udu protein in angiogenesis;
- in collaboration with physician scientists to study migraine comorbidity and spinocerebellar ataxia;
- to collaboratively study the cell specification of epidermal mucous cells
HONORS & AWARDS
| 2007 | (2007) UK-Singapore Partners in Science Collaboration Development Awards |
| 1999 – 2001 | (1999/1-2001/8) Imperial Cancer Research Fund (ICRF) Research Fellowship (UK) |
| 1997 – 1999 | (1997/1-1998/12) European Molecular Biology Organization (EMBO) Fellowship (EU) |
| 1992 – 1997 | (1992/8-1996/12) Deutscher Akademischer Austauschdienst (DAAD) Stipendium (FRG) |
| 1986 – 1988 | (1986/9-1988/6) Graduate Studentship from the Ministry of Education (Taiwan/ROC) |
SELECTED PUBLICATIONS
1. Jiang, Y.-J.*, Brand, M., Heisenberg, C.-P., Beuchle, D., Furutani-Seiki, M., Kelsh, R. N., Warga, R. M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D. A., Mullins, M. C., Odenthal, J., van Eeden, F. J. M. and Nüsslein-Volhard, C. (1996). Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development 123, 205-216. (IF=9.182; cited=254)
2. Jiang, Y.-J., Aerne, B. L., Smithers, L., Haddon, C., Ish-Horowicz, D. and Lewis, J. (2000). Notch signalling and the synchronization of the somite segmentation clock. Nature, 408, 475-479; doi :10.1038/35044091. (recommended in Faculty of 1000, 12/2001) (IF=29.491; cited=383)
3. Itoh,M., Kim, C.-H., Palardy, G., Oda, T., Jiang, Y.-J., Maust, D., Yeo, S.-Y., Lorick, K., Wright, G. J., Ariza-McNaughton, L., Weissman, A. M., Lewis, J., Chandrasekharappa, S. C. and Chitnis, A. B. (2003). Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev. Cell 4, 67-82; doi: 10.1016/S1534-5807(02)00409-4. (recommended in Faculty of 1000, 1/2003) (IF=11.531; cited=595)
4. Ma, M. and Jiang, Y.-J.* (2007). Jagged2a-Notch signaling mediates cell fate choice in zebrafish pronephric duct. PLoS Genet., 3, e18; doi: 10.1371/journal.pgen.0030018. (IF=7.671; cited=85)
5. Lim, C.-H., Chong, S.-W. and Jiang, Y.-J.* (2009). Udu deficiency activates DNA damage checkpoint. Mol. Biol. Cell, 20, 4183-4193; doi: 10.1091/mbc.E09-02-0109. (IF=5.558; cited=11)
6. Tse, W. K. F., Eisenhaber, B., Ho, S. H.-K., Ng, Q., Eisenhaber, F. and Jiang, Y.-J.* (2009). Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics, 10, 637; doi: 10.1186/1471-2164-10-637. (IF=3.926; cited=48)
7. Tseng, L.-C., Zhang, C., Cheng, C.-M., Xu, H., Hsu, C.-H. and Jiang, Y.-J.* (2014). New classes of Mind bomb-interacting proteins identified from yeast two-hybrid screens. PLoS ONE, 9, e93394; doi: 10.1371/journal.pone.0093394. (IF=3.534; cited=20)
8. Hsu, C.-H., Lin, J.-S., Lai, K. P., Li, J.-W., Chan, T.-F., You, M.-S., Tse, W. K. F. and Jiang, Y.-J.* (2015). A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect. Sci. Rep., 5, 10673; doi: 10.1038/srep10673. (IF=5.578; cited=5)
9. Wu, J.-H., Liu, J.-H., Ko, Y.-C., Wang, C.-T., Chung, Y.-C., Chu, K.-C., Liu, T.-T., Chao, H.-M., Jiang, Y.-J.* Chen, S.-J. and Chung, M.-Y. (2016). Haploinsufficiency of RCBTB1 is associated with Coats Disease and Familial Exudative Vitreoretinopathy. Hum. Mol. Genet., 25, 1637-1647; doi: 10.1093/hmg/ddw041. (*co-corresponding author). (IF=5.985; cited=25)
10. Hsu, C.-H., Liou, G.-G. and Jiang, Y.-J.* (2020). Nicastrin deficiency induces Tyrosinase-dependent depigmentation and skin inflammation. J. Invest. Derma., 140, 404-414; doi: 10.1016/j.jid.2019.07.702. (IF=7.143; cited=1)
Lab Members
