江運金副研究員

江運金 副研究員
分子與基因醫學研究所
電話: 886-37-206166 # 35348
E-mail:yjjiang@nhri.edu.tw

 

 

 

 

學歷

1992/10 – 1997/01Ph.D., Genetics/Developmental Biology, Eberhard-Karls Universitaet (Tuebingen University), Germany
1986/09 – 1998/06M.Sc., Biochemistry, National Taiwan University, Taiwan
1982/09 – 1986/06B.Sc., Agricultural Chemistry, National Taiwan University, Taiwan

經歷

2009/09 – presentAssiciate  Investigator, Division of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan
2008/01 – 2009/09Adjunct Associate Professor, Department of Biochemistry, National University of Singapore, Singapore
2006/10 – 2009/06Adjunct Associate Professor, School of Biological Sciences, Nanyang Technological University, Singapore
2003/04 – 2009/09Faculty, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore
2003/03 – 2007/12Adjunct Assistant Professor, Department of Biochemistry, National University of Singapore, Singapore
2002/08 – 2009/09Principal Investigator, Laboratory of Developmental Signalling and Patterning, Institute of Molecular and Cell Biology, Singapore
2001/09 – 2002/07Principal Investigator, Laboratory of Developmental Signalling and Patterning, Institute of Molecular Agrobiology, Singapore
1997/01 – 2001/08Postdoc, Vertebrate Development Laboratory,Imperial Cancer Research Fund, UK

研究興趣

The research interest of our lab is focusing on animal development and human diseases by using zebrafish as a model organism. We have studied the functions of Notch and Wnt signaling in different developmental processes and disease context. Recently, the focus has gradually shifted to the IMGM thematic project: lipid metabolism and human diseases.

Ubiquitylation and deubiquitylation are important protein posttranslational modification. We have investigated this issue both in basic developmental processes and human diseases. In the future, we would like to examine the interactions and/or crosstalks between ubiquitylation/deubiquitylation and lipid metabolism-related human diseases. Presently, the lab is focusing on Mindbomb (Mib), a novel component of Notch signaling, and Ugly duckling (Udu), a novel protein that is likely be required for DNA replication and other processes. The ongoing projects are

  • to study how Zranb1 and Mib1 modulate zebrafish convergent extension through regulating Ryk trafficking;
  • to study the mechanisms of Udu/GON4L on lipid metabolism and hepatocarcinogenesis;
  • to study the functions of zebrafish Udu protein in angiogenesis;
  • in collaboration with physician scientists to study migraine comorbidity and spinocerebellar ataxia;
  • to collaboratively study the cell specification of epidermal mucous cells.

榮譽與獲獎

2007(2007) UK-Singapore Partners in Science Collaboration Development Awards
1999 – 2001(1999/1-2001/8) Imperial Cancer Research Fund (ICRF) Research Fellowship (UK)
1997 – 1999(1997/1-1998/12) European Molecular Biology Organization (EMBO) Fellowship (EU)
1992 – 1997(1992/8-1996/12) Deutscher Akademischer Austauschdienst (DAAD) Stipendium (FRG)
1986 – 1988(1986/9-1988/6) Graduate Studentship from the Ministry of Education (Taiwan/ROC)

學術著作

1. Jiang, Y.-J.*, Brand, M., Heisenberg, C.-P., Beuchle, D., Furutani-Seiki, M., Kelsh, R. N., Warga, R. M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D. A., Mullins, M. C., Odenthal, J., van Eeden, F. J. M. and Nüsslein-Volhard, C. (1996). Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerioDevelopment 123, 205-216. (IF=9.182; cited=254)

2. Jiang, Y.-J., Aerne, B. L., Smithers, L., Haddon, C., Ish-Horowicz, D. and Lewis, J. (2000). Notch signalling and the synchronization of the somite segmentation clock. Nature, 408, 475-479; doi :10.1038/35044091. (recommended in Faculty of 1000, 12/2001) (IF=29.491; cited=383)

3. Itoh,M., Kim, C.-H., Palardy, G., Oda, T., Jiang, Y.-J., Maust, D., Yeo, S.-Y., Lorick, K., Wright, G. J., Ariza-McNaughton, L., Weissman, A. M., Lewis, J., Chandrasekharappa, S. C. and Chitnis, A. B. (2003). Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev. Cell 4, 67-82; doi: 10.1016/S1534-5807(02)00409-4. (recommended in Faculty of 1000, 1/2003) (IF=11.531; cited=595)

4. Ma, M. and Jiang, Y.-J.* (2007). Jagged2a-Notch signaling mediates cell fate choice in zebrafish pronephric duct. PLoS Genet., 3, e18; doi: 10.1371/journal.pgen.0030018. (IF=7.671; cited=85)

5. Lim, C.-H., Chong, S.-W. and Jiang, Y.-J.* (2009). Udu deficiency activates DNA damage checkpoint. Mol. Biol. Cell, 20, 4183-4193; doi: 10.1091/mbc.E09-02-0109. (IF=5.558; cited=11)

6. Tse, W. K. F., Eisenhaber, B., Ho, S. H.-K., Ng, Q., Eisenhaber, F. and Jiang, Y.-J.* (2009). Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics, 10, 637; doi: 10.1186/1471-2164-10-637. (IF=3.926; cited=48)

7. Tseng, L.-C., Zhang, C., Cheng, C.-M., Xu, H., Hsu, C.-H. and Jiang, Y.-J.* (2014). New classes of Mind bomb-interacting proteins identified from yeast two-hybrid screens. PLoS ONE, 9, e93394; doi: 10.1371/journal.pone.0093394. (IF=3.534; cited=20) 

8. Hsu, C.-H., Lin, J.-S., Lai, K. P., Li, J.-W., Chan, T.-F., You, M.-S., Tse, W. K. F. and Jiang, Y.-J.* (2015). A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect. Sci. Rep., 5, 10673; doi: 10.1038/srep10673. (IF=5.578; cited=5)

9. Wu, J.-H., Liu, J.-H., Ko, Y.-C., Wang, C.-T., Chung, Y.-C., Chu, K.-C., Liu, T.-T., Chao, H.-M., Jiang, Y.-J.* Chen, S.-J. and Chung, M.-Y. (2016). Haploinsufficiency of RCBTB1 is associated with Coats Disease and Familial Exudative Vitreoretinopathy. Hum. Mol. Genet., 25, 1637-1647; doi: 10.1093/hmg/ddw041. (*co-corresponding author). (IF=5.985; cited=25)

10. Hsu, C.-H., Liou, G.-G. and Jiang, Y.-J.* (2020). Nicastrin deficiency induces Tyrosinase-dependent depigmentation and skin inflammation. J. Invest. Derma., 140, 404-414; doi: 10.1016/j.jid.2019.07.702. (IF=7.143; cited=1)

Review articles

1. Jiang, Y.-J., Smithers, L. and Lewis, J. (1998). Somite segmentation: the clock is linked to Delta-Notch signalling. Curr. Biol. 8, R868-R871.

2. Rida, P. C. G., Le Minh, N. and Jiang, Y.-J.* (2004). A Notch feeling of somite segmentation and beyond. Dev. Biol. 265, 2-22.

3. Chong, S.-W. and Jiang, Y.-J.* (2005). Off limits – Integrins holding boundaries in somitogenesis. Trends Cell Biol., 15, 453-457.

4. Chong, S.-W., Korzh, V. and Jiang, Y.-J. (2009). Myogenesis and molecules – insights from zebrafish Danio rerio. J. Fish Biol. 74, 1693-1755.

Book chapters

1. Jiang, Y.-J. and Lewis, J. (2001). Notch as a synchroniser in somite segmentation. In the Proceedings of the NATO Advanced Research Workshop on The Origin and Fate of Somites, Sanders, E. J., Lash, J. W. and Ordahl, C. P. (eds.), Series I – Life and Behavioural Sciences, Vol 329, 71-79. IOS Press, Amsterdam.

2. Jiang, Y.-J.* (2004). Vertebrate somite development, Notch signalling and others. In Fish Development and Genetics – the Zebrafish and Medaka Models, Gong, Z. and Korzh, V. (eds.), Book series of “Molecular Aspects of Fish and Marine Biology”, Vol. 2, 294-338. World Scientific Publishing, Singapore.

3. You, M.-S. and Jiang, Y.-J.* (2007). Drug discovery using zebrafish. In Drug Discovery 2007, Taheri-Panah, S. (ed.), 42-43. Touch Briefings, London.

4. Tse, W. K. F. and Jiang, Y.-J. (2012). Functional screen of zebrafish deubiquitylating enzymes by morpholino knockdown and in situ hybridization. In Functional Genomics: Methods and Protocols, Second Edition, Kaufmann, M. and Klinger, C. (eds.), Book series of “Methods in Molecular Biology”, Vol. 815, 321-331. Humana Press, New York, USA.

5. Tseng, L.-C., Tang, C.-H. and Jiang, Y.-J.* (2016). Morphology and gene expression screening with morpholinos in zebrafish embryos. In High-Throughput RNAi Screening, Azorsa, D. and Arora, S. (eds.), Book series of “Methods in Molecular Biology”, Vol. 1470, 213-224. Humana Press, New York, USA.

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